Caris Life Sciences, Inc. (CAI)

Caris Life Sciences, Inc., an artificial intelligence TechBio company, provides molecular profiling services in the United States and internationally. It develops and commercializes solutions to transform healthcare using molecular information, and artificial intelligence/machine learning algorithms. The company's molecular intelligence product portfolio includes MI Profile Platform, a whole exome sequencing (WES)/ whole transcriptome sequencing (WTS) tissue-based molecular profiling solutions; Caris Assure Platform WES/WTS blood-based molecular profiling solutions; Precision Whole Genome Platform, a whole genome sequencing (WGS) blood- and tissue-based profiling solutions; and Caris Detect, a WGS-based multi-cancer early detection solution; Caris WGS MRD a WGS and digital droplet polymerase reaction-based minimal residual disease solution; and Caris ChromoSeq, a WGS and WTS based assay for therapy selection in hematological cancers. It also offers pharma research and development services comprising laboratory delivery, strategic data, and research services to biopharmaceutical customers. The company provides its precision oncology solutions to customers, such as hospitals, institutions and patients. The company was founded in 2008 and is headquartered in Irving, Texas.

Ticker
CAI
Exchange
Nasdaq
Sector
Healthcare
Industry
Biotechnology
Market cap
$7.23B
52-week range
$14.19 - $36.50

Valuation

Share price
$25.23 (close of Nov 6, 2026)
P/E (TTM)
3.05x
Price to book
11.31x
Price to free cash flow
250.22x
Enterprise value
$7.70B
Book value per share
$2.23

Price performance

PeriodChange
1 day-3.07%
5 days-26.51%
1 month-8.09%
3 months+26.15%
6 months+31.89%
Year to date-6.49%
1 year+2.52%
All time-9.89%

Short interest

As of
Oct 15, 2026
Short % of float
11.80%
Shares short
13.59M
Days to cover
3.23
Change since prior report
-2.18%
Source
FINRA consolidated short interest

Profitability and growth

Return on equity
-11.79%
Return on invested capital
4.49%
Return on assets
-6.05%
Return on capital employed
4.52%
Gross margin
66.40%
Net margin
-8.38%
EBITDA margin
8.34%
Revenue growth
96.97%

Cash flow and balance sheet

Free cash flow yield (TTM)
0.40%
Current ratio
6.71x
Net debt to EBITDA
2.97x

Latest reported year

Period end
Dec 31, 2025
Fiscal year
2025
Revenue
$812.03M
Cost of revenue
$272.87M
Gross profit
$539.17M
EBITDA
$67.73M
Net income
-$68.09M
Earnings per share
$-3.22
Research and development
$101.58M
Interest expense
$56.85M
Shares outstanding
167.21M

Income statement by year

Period endRevenueGross profitNet incomeEPS
2025-12-31$812.03M$539.17M-$68.09M-$3.22
2024-12-31$412.26M$178.78M-$281.89M-$10.66
2023-12-31$306.13M$89.31M-$341.42M-$13.24

Margins and returns by year

Period endGross marginNet marginReturn on equityReturn on capital
2025-12-3166.40%-8.38%-11.79%4.49%
2024-12-3143.37%-68.38%--
2023-12-3129.17%-111.53%--

Cash and debt by year

Period endCashDebt
2025-12-31$796.27M$378.82M
2024-12-31$63.95M$319.44M

Free cash flow by year

Period endFree cash flowStock-based compensation
2025-12-31$66.89M$70.01M
2024-12-31-$253.64M$18.64M
2023-12-31-$298.42M$15.24M

Investor relations

Past earnings dates

ReportedFiscal periodEPS estimate
2026-11-04Sep 2026$0.03
2026-08-05Jun 2026-$0.01
2026-05-07Mar 2026-$0.02
2026-02-26Dec 2025$0.01
2025-11-05Sep 2025-$0.08
2025-08-12Jun 2025-$0.21
2011-10-27--
2011-07-26--

Filings and sources

Company website
carislifesciences.com
SEC filings
10-K, 10-Q and 8-K on EDGAR
Earnings calendar
All upcoming reports

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