Nurix Therapeutics, Inc. (NRIX)

Nurix Therapeutics, Inc., a clinical stage biopharmaceutical company, focuses on the discovery, development, and commercialization of small molecule and antibody therapies for the treatment of cancer, inflammatory conditions, and other diseases. The company develops NX-5948, an orally bioavailable BTK degrader, that is in Phase 2 clinical trials for the treatment of relapsed or refractory B-cell malignancies and autoimmune diseases; NX-2127, an orally bioavailable Bruton's tyrosine kinase (BTK) degrader, that is in Phase Phase 1a/1b clinical trials for the treatment of relapsed or refractory B-cell malignancies; and NX-1607, an orally bioavailable Casitas B-lineage lymphoma proto-oncogene-B (CBL-B) inhibitor, that is in Phase 1a/1b clinical trials to treat immuno-oncology indications. It is also developing NX-0479/GS-6791, a IRAK4 degrader for the treatment of rheumatoid arthritis and other inflammatory diseases. The company has a strategic collaboration agreement with Gilead Sciences, Inc. (Gilead), Sanofi S.A. (Sanofi), and Pfizer Inc. (Pfizer) for co-development and co-commercialization for multiple drug candidates. The company was formerly known as Nurix Inc. and changed its name to Nurix Therapeutics, Inc. in October 2018. Nurix Therapeutics, Inc. was incorporated in 2009 and is headquartered in Brisbane, California.

Symbol
NRIX
Exchange
Nasdaq
Sector
Healthcare
Industry
Biotechnology
Market cap
$2.38B
52 week range
8.85 - 28.23

Valuation

Share price
$22.99 (close of 2026-10-02)
P/E (TTM)
-6.64x
Price to book
5.92x
Price to free cash flow
-7.83x
Enterprise value
$2.00B
Book value per share
$3.88

Price performance

PeriodChange
1 day-1.50%
5 days-0.09%
1 month-10.96%
3 months-4.09%
6 months+48.23%
Year to date+21.19%
1 year+153.19%
3 years+217.98%
5 years-26.41%
All time+20.94%

Profitability and growth

Return on equity
-49.09%
Return on invested capital
-18114.52%
Return on assets
-38.43%
Return on capital employed
-47.48%
Net margin
-314.90%
EBITDA margin
-329.75%
Revenue growth
53.95%
Net income growth
-36.62%
Free cash flow growth
-44.88%

Cash flow and balance sheet

Free cash flow yield (TTM)
-12.77%
Current ratio
6.34x
Net debt to EBITDA
1.12x

Latest reported year

Period end
2025-11-30
Fiscal year
2025
Revenue
$83.98M
EBITDA
-$276.93M
Net income
-$264.46M
Earnings per share
$-3.05
Research and development
$316.90M
Shares outstanding
86.67M

Income statement by year

Period endRevenueNet incomeEPS
2025-11-30$83.98M-$264.46M$-3.05
2024-11-30$54.55M-$193.57M$-2.88
2023-11-30$76.99M-$143.95M$-2.65
2022-11-30$38.63M-$180.36M$-3.71
2021-11-30$29.75M-$117.19M$-2.73
2020-11-30$17.82M-$43.24M$-2.76
2019-11-30$31.11M-$21.70M$-6.59

Margins and returns by year

Period endNet marginReturn on equityReturn on capital
2025-11-30-314.90%-49.09%-18114.52%
2024-11-30-354.85%-36.73%-
2023-11-30-186.98%-71.80%-
2022-11-30-466.93%-59.39%-2802.85%
2021-11-30-393.93%-34.24%-197.67%
2020-11-30-242.66%-14.90%-487.31%
2019-11-30-69.74%37.60%-

Cash and debt by year

Period endCash
2025-11-30$592.90M
2024-11-30$609.60M
2023-11-30$287.90M
2022-11-30$309.10M
2021-11-30$295.70M
2020-11-30$281.15M
2019-11-30$37.72M

Free cash flow by year

Period endFree cash flowStock-based compensation
2025-11-30-$263.47M$37.97M
2024-11-30-$181.86M$33.93M
2023-11-30-$89.77M$33.67M
2022-11-30-$172.05M$28.13M
2021-11-30-$90.03M$15.80M
2020-11-30-$4.63M$4.30M
2019-11-30-$1.05M$510.00K

Investor relations

Next earnings report

Next confirmed report
2026-10-08
Consensus EPS estimate
$-0.56

Past earnings dates

ReportedFiscal periodEPS estimate
2026-07-09May/2026$-0.73
2026-04-08Feb/2026$-0.76
2026-01-28Nov/2025$-0.84
2025-10-09Aug/2025$-0.84
2025-07-09May/2025$-0.71
2025-04-08Feb/2025$-0.72
2025-01-28Nov/2024$-0.67
2024-10-11Aug/2024$-0.67

Filings and sources

Company website
nurixtx.com
SEC filings
10-K, 10-Q and 8-K on EDGAR
Earnings calendar
All upcoming reports

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